The experts in biophsyics

Get the best tools and resources for buffer screening and optimization, formulation development and biologics development here from 2bind.

Buffer screening made easy for your antibodies. The FORMOscreen® line provides unique and ready-to-use buffers for optimizing antibody stability. All buffers were designed by antibody formulation experts and are proven to be beneficial for stability and storage of therapeutic antibodies. All buffers are approved by the FDA and/or EMA for use in antibody formulations.

Coming soon!

In the meantime, although designed for antibodies, the FORMOscreen® buffer line works great with other proteins, too. Check out our application note below, showing how to improve the formulation of an HIV-vaccine protein!

Coming soon!

We are currently developing special buffer screens for optimizing the formulation of Adenovirus (AV) or Adeno-associated virus (AAV) particles. Stay tuned!

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From scientists for scientists

Benefit from our 10-year experience in bioanalytics and biophysics.

Their science and professionalism are impeccable – working with 2bind is like having expert biophysicists in the lab next door.

Christopher Lepre, Relay Therapeutics

We used the services of 2bind several times [...] and were always happy with the excellent service and result quality.

Philipp Richle, CDR-Life AG

The highly reproducible nanoDSF data provided important information on the stability of our proteins under diverse buffer conditions.

Martin Griessl, Lysando AG

Resources

Multi-parameter formulation development for an HIV-vaccine protein with direct validation of epitope binding integrity and stoichiometry

Vaccines are on the front line-of-defense against infectious diseases, ranging from threats we are familiar with, including polio, tuberculosis, or HIV, to novel and emerging threats such as SARS-CoV-2. Successful development of new protein-based vaccines requires sophisticated and efficient development of storage and formulation conditions. Here we demonstrate the combined power of 2bind’s sophisticated buffer matrix FORMOscreen® and NanoTemper Technologies’ novel Prometheus Panta high-throughput Dynamic Light Scattering/Nano Differential Scanning Fluorimetry instrument. We show that this combination can comprehensively improve critical biophysical parameters for the HIV-1 vaccine BG505-SOSIP and find the optimal formulation condition with unmatched efficiency.

Read on BioRxiv.